| RUSHING | ATT | YDS | AVG | LONG | TD |
| Frank Gore | 13 | 91 | 7.0 | 64t | 1 | | Alex Smith | 1 | 10 | 10.0 | 10 | 0 | | Glen Coffee | 1 | 8 | 8.0 | 8 | 0 | | Moran Norris | 3 | 4 | 1.3 | 3 | 0 |
| |
| RUSHING | ATT | YDS | AVG | LONG | TD |
| Joseph Addai | 20 | 62 | 3.1 | 13 | 0 | | Chad Simpson | 1 | -1 | -1.0 | -1 | 0 |
|
| PASSING | COMP | ATT | YDS | LONG | TD | INT |
| Alex Smith | 19 | 32 | 198 | 27 | 1 | 1 |
| |
| PASSING | COMP | ATT | YDS | LONG | TD | INT |
| Joseph Addai | 1 | 1 | 22 | 22t | 1 | 0 | | Peyton Manning | 31 | 48 | 347 | 40 | 0 | 0 |
|
| RECEIVING | NO | YDS | AVG | LONG | TD |
| Frank Gore | 5 | 43 | 8.6 | 15 | 0 | | Michael Crabtree | 6 | 81 | 13.5 | 27 | 0 | | Isaac Bruce | 4 | 51 | 12.8 | 20 | 0 | | Vernon Davis | 3 | 20 | 6.7 | 10 | 1 | | Josh Morgan | 1 | 3 | 3.0 | 3 | 0 |
| |
| RECEIVING | NO | YDS | AVG | LONG | TD |
| Joseph Addai | 2 | 4 | 2.0 | 2 | 0 | | Reggie Wayne | 12 | 147 | 12.2 | 32 | 1 | | Dallas Clark | 8 | 99 | 12.4 | 40 | 0 | | Austin Collie | 6 | 66 | 11.0 | 23 | 0 | | Pierre Garcon | 4 | 53 | 13.2 | 32 | 0 |
|
| FUMBLES | NO | LOST |
| Michael Crabtree | 1 | 1 | | Nate Clements | 1 | 0 |
| |
| FUMBLES | NO | LOST |
| Dallas Clark | 1 | 0 | | Jamie Silva | 1 | 0 |
|
| INTERCEPTIONS | NO | YDS | LONG | TDS |
| |
| INTERCEPTIONS | NO | YDS | LONG | TDS |
| Bob Sanders | 1 | 29 | 29 | 0 |
|
| PUNTING | NO | AVG | LONG | IN 20 | TB |
| Andy Lee | 8 | 50 | 59 | 4 | 0 |
| |
| PUNTING | NO | AVG | LONG | IN 20 | TB |
| Pat McAfee | 7 | 46 | 60 | 2 | 0 |
|
| PUNT RETURNS | NO | YDS | LONG | TDS |
| Nate Clements | 4 | 31 | 12 | 0 | | Brandon Jones | 2 | 6 | 3 | 0 |
| |
| PUNT RETURNS | NO | YDS | LONG | TDS |
| Jamie Silva | 6 | 32 | 7 | 0 |
|
| KICKOFF RETURNS | NO | YDS | LONG | TDS |
| Michael Robinson | 5 | 99 | 26 | 0 | | Kentwan Balmer | 1 | 3 | 3 | 0 |
| |
| KICKOFF RETURNS | NO | YDS | LONG | TDS |
| Chad Simpson | 3 | 64 | 26 | 0 |
|
| DEFENSE | TK | AS | SK-YDS | PD |
| Glen Coffee | 1 | 1 | 0 | 0 | | Isaac Bruce | 1 | 0 | 0 | 0 | | Josh Morgan | 1 | 0 | 0 | 0 | | Andy Lee | 0 | 1 | 0 | 0 | | Michael Robinson | 1 | 0 | 0 | 0 | | Kentwan Balmer | 1 | 0 | 0 | 0 | | Nate Clements | 2 | 0 | 0 | 0 | | Dashon Goldson | 9 | 1 | 0 | 1 | | Shawntae Spencer | 8 | 0 | 0 | 1 | | Patrick Willis | 6 | 2 | 0 | 1 | | Takeo Spikes | 5 | 3 | 0 | 0 | | Justin Smith | 3 | 4 | 0 | 0 | | Michael Lewis | 5 | 0 | 0 | 1 | | Marcus Hudson | 4 | 0 | 0 | 0 | | Isaac Sopoaga | 3 | 1 | 1-8 | 0 | | Manny Lawson | 3 | 1 | 0 | 0 | | Aubrayo Franklin | 3 | 0 | 1-5 | 0 | | Mark Roman | 2 | 0 | 0 | 0 | | Arnaz Battle | 2 | 0 | 0 | 0 | | Tarell Brown | 2 | 0 | 0 | 0 | | Ray McDonald | 1 | 0 | 1-7 | 0 | | Chilo Rachal | 1 | 0 | 0 | 0 | | Dre' Bly | 1 | 0 | 0 | 1 | | Matt Wilhelm | 1 | 0 | 0 | 0 | | Parys Haralson | 1 | 0 | 0 | 0 | | Curtis Taylor | 0 | 1 | 0 | 0 | | Brian Jennings | 0 | 1 | 0 | 0 | | Scott McKillop | 0 | 1 | 0 | 0 |
| |
| DEFENSE | TK | AS | SK-YDS | PD |
| Jamie Silva | 4 | 0 | 0 | 0 | | Clint Session | 8 | 0 | 0 | 0 | | Antoine Bethea | 5 | 2 | 0 | 0 | | Philip Wheeler | 3 | 3 | 1-0 | 0 | | Jerraud Powers | 5 | 0 | 0 | 1 | | Gary Brackett | 4 | 1 | 0 | 0 | | Kelvin Hayden | 4 | 0 | 0 | 0 | | Freddy Keiaho | 2 | 2 | 0 | 0 | | Tyjuan Hagler | 0 | 4 | 0 | 0 | | Antonio Johnson | 2 | 1 | 1-3 | 0 | | Ramon Humber | 2 | 1 | 0 | 0 | | Jacob Lacey | 2 | 1 | 0 | 0 | | Dwight Freeney | 2 | 0 | 1-5 | 0 | | Tim Jennings | 2 | 0 | 0 | 0 | | Daniel Muir | 2 | 0 | 0 | 0 | | Robert Mathis | 1 | 1 | 1-8 | 0 | | Melvin Bullitt | 1 | 1 | 0 | 0 | | Bob Sanders | 1 | 1 | 0 | 1 | | Aaron Francisco | 1 | 0 | 0 | 0 |
|